Spina bifida and anencephaly: are miscarriages a possible cause?
نویسندگان
چکیده
The marriage-to-conception interval in 151 pregnancies producing infants with anencephaly or spina bifida was not significantly different from that in 218 pregnancies resulting in normal infants. Significantly more miscarriages occurred before than after the birth of 285 infants with anencephaly or spina bifida, but in 133 controls no before-after difference was observed. These observations seem to favour the idea that miscarriages are a manifestation rather than a cause of anencephaly and spina bifida.
منابع مشابه
Birth ranks of spontaneous abortions in sibships of children affected by anencephaly or spina bifida.
Data on the birth ranks of miscarriages within sibships in which a case of anencephaly or spina bifida (ASB) had occurred were analysed by the Haldane-Smith statistical test. This showed that miscarriages in ASB sibships tend to have a negative birth order effect--that is, they occur in earlier rather than later pregnancies within the sibship. The strongest source of bias in this analysis--the ...
متن کاملBrief communication: possible X-linked anencephaly and spina bifida--report of a kindred.
Causal heterogeneity of anencephaly and spina bifida has been demonstrated; in rare families the neural tube defect may be caused by a single gene. We report a family in which four cases of anencephaly or spina bifida may represent X-linked inheritance.
متن کاملAnencephaly and spina bifida (ASB) and retroversion.
Despite the wealth of epidemiological material of the last decade, birth defects are still the chief cause of perinatal mortality and no significant breakthrough in understanding or reduction has yet been seen. Many proposed aetiological factors are still being evaluated. This report suggests a possible, simple, remediable factor in the aetiology of defects of the central nervous system.
متن کاملThe range of neural tube defects in southern India.
During a prospective study of 3500 consecutive births from November 1985 to January 1987 at three hospitals, 40 babies were found to have neural tube defects, an extremely high incidence (11.4/1000 births). The defects comprised anencephaly (n = 18), meningomyelocele (n = 11), Arnold-Chiari deformity (n = 3), encephalocele (n = 3), iniencephaly (n = 2), and one each of occipital meningocele, sp...
متن کاملSpina bifida and anencephaly in Scotland.
Data obtained from routine sources showed that from 1971 to 1982 the birth prevalences of spina bifida and anencephaly in Scotland fell. When known terminations after routine alpha fetoprotein screening were added to total births the adjusted birth prevalence could be calculated. In 1974-82 this fell by 40% for spina bifida (3 X 0-1 X 8) and 36% for anencephaly (2 X 2-1 X 4). These findings wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 2 6083 شماره
صفحات -
تاریخ انتشار 1977